Thanksgiving brings a trio of NFL games, with the closest matchup on paper arriving in the evening window. NFC West powers will square off when the Seattle Seahawks host the San Francisco 49ers at Lumen Field. It is the first of two scheduled meetings between the division-rivals this season and Seattle is 4-1 at home in 2023. The Seahawks are also 6-4 overall, and the 49ers enter at 3-2 on the road and 7-3 overall.Kickoff is at 8:20 p.m. ET in Seattle. For this game, SportsLine consensus lists San Francisco as a seven-point favorite, while the over/under, or total number of points Vegas thinks will be scored, is 44 in the latest 49ers vs. Seahawks odds. Before making any Seahawks vs. 49ers picks, be sure Tanner Roark Jersey to .Nagel is a Reno-based analyst and radio host who has worked in the sports handicapping industry for more than 20 years. SportsLine's a sistant managing editor has covered the wagering industry on a variety of platforms, and has won numerous sports handicapping contests.Moreover, Nagel has a read on the pulse of the Seahawks. In fact, he is a blistering 24-10 (+1300) on his last 34 in games involving Seattle. Anyone who has Joe Morgan Jersey followed him is way up. Now, he has locked in on during the 2023 Thanksgiving NFL schedule and released a confident against-the-spread pick. . Here are the and trends for Seahawks vs. 49ers:49ers vs. Seahawks spread: 49ers -749ers vs. Seahawks over/under: 44 points49ers vs. Seahawks money line: 49ers -352, Seahawks +274SF: 49ers are 5-5 against the spread this seasonSEA: Seahawks are 5-4-1 against the spread this season49ers vs. Seahawks picks: 49ers vs. Seahawks live stream: (try for free)49ers quarterback Brock Purdy leads the NFL with a 77.1 QBR and 115.1 pa ser rating this season and posted a perfect pa ser rating (158.3) against the Tampa Bay Buccaneers in Week 11. Purdy also leads the league in completion rate (70.2%) and yards per George Foster Jersey pa s attempt (9.7) and is only the fourth quarterback ever with at least a 70% completion rate and at least 9.0 yards per attempt through 10 weeks.Purdy is also in the top eight of the NFL in pa sing touchdowns (18) and total offense (2,657) and has six touchdowns and no turnovers in two games against Seattle. Purdy and the 49ers are also facing a potentially vulnerable Seattle defense. The Seahawks are in the bottom third of the league in total yards allowed and first downs allowed this season, and Seattle ranks No. 27 in red zone efficiency allowed (63.0%) and No. 29 in third down efficiency allowed (44.0%).. The Seahawks take care Anthony DeSclafani Jersey of the ball at a strong level, losing only three fumbles and committing only 11 giveaways this season. Seattle also stands to benefit from San Francisco's i sues in third down efficiency (40.9%) and red zone efficiency (54.2%). Seattle has been a better team at home this season, including an active four-game winning streak, and is averaging almost 28 points per game over that stretch.Seattle's offense has been highly efficient, including 5.8 yards per play, at Lumen Field, and the Seahawks are also playing well on defense, giving up only 18.6 points per game over the last seven. Despite the lo s a week ago, Seattle held Los Angeles to only 4.5 yards per play and 267 total yards and six-time All-Pro Bobby Wagner is a force in the middle of the defense. Wagner has at least 100 tackles in 12 straight seasons and is in the top five of the league with 105 tackles in 2023..Nagel has analyzed this matchup and while we can tell you he's leaning Over the total, he has discovered a crucial x-factor that makes one side of the spread a must-back. . Who wins 49ers vs. Seahawks as part Pete Rose Jersey of the NFL Thanksgiving Day schedule 2023, and what critical factor makes one side of the spread a must-back? , and find out.